Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila
نویسندگان
چکیده
منابع مشابه
Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila.
Transposable elements (TEs) are mobile genetic elements, highly enriched in heterochromatin, that constitute a large percentage of the DNA content of eukaryotic genomes. Aging in Drosophila melanogaster is characterized by loss of repressive heterochromatin structure and loss of silencing of reporter genes in constitutive heterochromatin regions. Using next-generation sequencing, we found that ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2016
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1604621113